KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Chemicals, Peptides, and Recombinant Proteins
Baclofen	Sigma-Aldrich	Catalog #: B5399
ML297	Sigma-Aldrich	Catalog #: SML0836
SCH23390	Sigma-Aldrich	Catalog #: D054
CGP55845	Sigma-Aldrich	Catalog #: SML0594
1-Propanol	Sigma-Aldrich	Catalog #: 402893
Barium Chloride	Sigma-Aldrich	Catalog #: 342920
Valproic acid	Sigma-Aldrich	Catalog #: P4543
Pentylenetetrazol	Sigma-Aldrich	Catalog #: P6500
Critical Commercial Assays
QuikChange II XL	Agilent Technology
Experimental Models: Cell Lines
HEK293T cells	ATCC	Catalog #: CRL-3216
Experimental Models: Organisms/Strains
C57BL6/J mice (male and female)	Jackson Labs	Wild-type
CD1 mice (male) used for in vivo pharmacokinetic (PK) studies	Pharmaron labs	https://www.pharmaron.com/
Oligonucleotides
DNA primers for mutagenesis	This study	N/A
Recombinant DNA
rat GIRK1_mouse GIRK2c dimer cDNA	Horvath et al., 2018	N/A
mouse GIRK2c cDNA	Horvath et al., 2018	N/A
rat GIRK1_mouse GIRK3 dimer cDNA	This study	N/A
mouse GIRK3 cDNA	Cruz et al., 2004	N/A
rat GIRK4 cDNA	Aryal et al., 2009	N/A
human GABAB1b cDNA	Horvath et al., 2018	N/A
human GABAB2 cDNA	Horvath et al., 2018	N/A
PTX S1 cDNA	This study	N/A
Software and Algorithms
Prism 7.0	Graphpad	RRID:SCR_002798
Schrödinger (2017a, 2017b), LigPrep, Glide	Schrödinger	https://www.schrodinger.com/; RRID: SCR_014879
MODELLER v9.18	(Šali and Blundell, 1993)	salilab.org/modeller; RRID: SCR_008395
MOE 2014.0901, 2016	Chemical Computing Group	https://www.chemcomp.com/; RRID: SCR_014882
OEDocking 3.2.0.2, FRED, OMEGA	OpenEye	https://www.eyesopen.com/; RRID: SCR_014880
KNIME		https://www.knime.com/; RRID: SCR_006164
JChem Cartridge	ChemAxon	https://chemaxon.com; RRID: SCR_004111
StarDrop	Optibrium	https://www.optibrium.com/stardrop/; RRID: SCR_014902
FIJI	ImageJ	http://fiji.sc; RRID: SCR_002285
PyMOL		https://pymol.org/2/; RRID: SCR_000305