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The iterative cycle for designing, synthesizing, and evaluating sAC inhibitors. Starting from LRE1, the workflow used to identify a preclinical development candidate includes activities performed in the Levin/Buck laboratory (light blue), the Steegborn laboratory (orange), or at TDI or TDI-managed CROs (green). In vitro efficacy models include both cell-based cyclase assay and in vitro efficacy mouse sperm. Structural biology information is used to model and design new compounds.
