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. 2020 Mar 17;61(3):25. doi: 10.1167/iovs.61.3.25

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Figure 1. — The homozygous Cx50(R205G/R205G) mutant lenses show more severe phenotype than the Cx50(–/–) knockout lenses. (A) Lens images of postnatal day 3 (P3) mice reveal early-onset growth defect and severe cataract in the homozygous Cx50(R205G/R205G) mutant lens, in comparison to the Cx50(+/+) wild-type and the Cx50(–/–) knockout lenses. The upper panels show lenses viewed from the anterior surface, while the lower panels display lenses viewed from the equator, and the anterior-posterior axis is from left to right. Scale bar: 1 mm. (B) Anterior view of fresh lenses of 3-week-old Cx50(+/+) wild-type, homozygous Cx50(R205G/R205G) and Cx50(–/–) knockout mice. Scale bar: 1 mm. (C) Lens volume comparison of P3 and P21 wild-type, homozygous Cx50(R205G/R205G), and Cx50(–/–) knockout mice. The P3 homozygous Cx50(R205G/R205G) lenses show approximately 40% reduction (P < 0.001) and the Cx50(–/–) knockout lenses have approximately 33% reduction (P < 0.001) when compared with the wild-type control. At P21, homozygous Cx50(R205G/R205G) lenses are approximately 64% smaller (P < 0.001) and the Cx50(–/–) knockout lenses are approximately 39% smaller (P < 0.001) than the wild-type lenses. Data are mean ± SD, n = 6–8 lenses of each genotype, with the Student's t-test for statistical analysis, ***P < 0.001, indicating statistically significant when compared with the wild-type.