Table 2. The association between statin therapy and 25(OH)D levels and its metabolites among older adults.
Model 1 adjusted for study period, age, gender, race/ethnicity, education, income, BMI, smoking status, alcohol use, and physical activity.
Model 2 adjusted for model 1 and self-reported health status, diabetes, and vitamin D intake.
| Vitamin D concentrations | Statin users (SE) | Non-users (SE) | Mean difference (SE) | P-value |
| 25(OH)D3 (nmol/L) | ||||
| Mean | 71.5 (1.0) | 69.8 (0.9) | 1.7 (0.9) | 0.081 |
| Model 1 | 72.9 (0.9) | 69.1 (0.8) | 3.8 (0.9) | <0.0001 |
| Model 2 | 72.4 (0.8) | 69.3 (0.7) | 3.1 (0.8) | <0.05 |
| 25(OH)D2 (nmol/L) | ||||
| Mean | 7.5 (0.7) | 5.6 (0.4) | 1.9 (0.6) | <0.05 |
| Model 1 | 7.5 (0.7) | 5.7 (0.4) | 1.8 (0.6) | <0.05 |
| Model 2 | 7.2 (0.7) | 5.8 (0.4) | 1.4 (0.6) | 0.054 |
| Total 25(OH)D (nmol/L) | ||||
| Mean | 79.0 (1.0) | 75.4 (0.8) | 3.6 (1.0) | <0.05 |
| Model 1 | 80.5 (1.0) | 74.8 (0.7) | 5.7 (0.9) | <0.0001 |
| Model 2 | 79.6 (0.8) | 75.2 (0.7) | 4.4 (1.0) | <0.0001 |