Figure 6.

Morphologic alterations in Bruch's membrane thickness and RPE basal infoldings in response to smoke and elastin immunization. Summary of alterations in Bruch's membrane thickness and basal infoldings obtained from EM images described in Figure 4. (A) BrM thickness was determined using the masks outlined in Figure 5, and the percent BrM along a given RPE cell that is damaged (exceed the normal thickness of BrM in age-matched room air–exposed mice) is established. A smoke and immunization effect could be established. (B) Basal infoldings were measured for both the lamellar portion and the open space in between. However, no consistent differences were observable. Data are expressed as mean ± SEM (n = 4–6 retinas per condition, representing 8–12 cells).