Table 2.
Baseline Characteristics of Eyes/Patients Considering Distinct DRSS Stages of the Disease
| Characteristic | Controls(n = 84) | EDTRS 10–20(n = 18) | EDTRS 35(n = 17) | EDTRS 43–47(n = 9) | P Value(Three DRSS Groups)* |
|---|---|---|---|---|---|
| VD SCP, mm−1 | |||||
| Mean (SD) [range] | 21.1 (0.7)[20.2–22.8] | 20.5 (1.0)[18.3–21.9] | 19.4 (1.6)[16.1–22.3] | 19.5 (1.8)[15.8–21.9] | 0.047 |
| P value† | 0.051 | <0.001 | 0.005 | ||
| VD DCP, mm−1 | |||||
| Mean (SD) [range] | 16.1 (1.8)[12.2–19.8] | 16.0 (1.5)[13.8–19.5] | 15.5 (2.1)[10.5–19.8] | 14.8 (2.9)[9.1–17.9] | 0.386 |
| P value† | 0.632 | 0.257 | 0.005 | ||
| VD FR, mm−1 | |||||
| Mean (SD) [range] | 22.4 (0.6)[21.2–24.2] | 22.2 (0.8)[20.4–23.3] | 21.4 (1.5)[18.2–24.0] | 21.1 (1.6)[17.6–23.3] | 0.072 |
| P value† | 0.510 | <0.001 | 0.006 | ||
| FAZ area, mm2 | |||||
| Mean (SD) [range] | 0.24 (0.11)[0.04–0.54] | 0.27 (0.12)[0.10–0.55] | 0.23 (0.12)[0.07–0.43] | 0.23 (0.08)[0.14–0.37] | 0.440 |
| P value† | 0.309 | 0.717 | 0.907 | ||
| FAZ circularity index | |||||
| Mean (SD) [range] | 0.65 (0.07)[0.39–0.87] | 0.68 (0.06)[0.58–0.79] | 0.62 (0.09)[0.39–0.75] | 0.60 (0.10)[0.37–0.70] | 0.019 |
| P value† | 0.104 | 0.260 | 0.887 | ||
| RNFL thickness, µm | |||||
| Mean (SD) [range] | 7.0 (3.4)[0.7–13.6] | 6.3 (2.9)[2.5–13.7] | 7.1 (3.4)[2.3–15.1] | 6.3 (1.8)[4.6–9.9] | 0.691 |
| P value† | 0.449 | 0.889 | 0.556 | ||
| GCL-IPL thickness, µm | |||||
| Mean (SD) [range] | 82.7 (5.5)[71–94] | 82.0 (6.6)[72–92] | 76.2 (7.4)[58–90] | 81.3 (8.4)[69–97] | 0.056 |
| P value† | 0.878 | 0.001 | 0.484 | ||
| Full retinal thickness, µm | |||||
| Mean (SD) [range] | 260.6 (18.3)[218–299] | 261.6 (25.2)[212–300] | 270.4 (30.1)[225–320] | 267.0 (27.0)[223–304] | 0.565 |
| P value† | 0.669 | 0.365 | 0.919 | ||
VD, Vessel Density. Values in bold indicate statistical significance.
*
P value for the Mann-Whitney test for comparison between the control and DRSS groups.
†
P value for the ANOVA test for comparison between the three DRSS groups.