Table 3.
Progression in Capillary Dropout, Neurodegeneration, and Edema After 1- and 2-Year Intervals in Different DRSS Groups
| Visit 1 | Visit 2 | Visit 3 | P Value | P Value | ||
|---|---|---|---|---|---|---|
| Characteristic | Mean (SD) | Mean (SD) | Mean (SD) | V2–V1* | V3–V1* | |
| ETDRS 10–20 (n = 18) | ||||||
| Vessel density, mm−1 | SCP | 20.5 (1.0) | 19.4 (1.3) | 18.8 (1.5) | 0.002 | <0.001 |
| DCP | 16.0 (1.5) | 14.7 (2.1) | 13.9 (1.9) | 0.012 | 0.001 | |
| FR | 22.2 (0.8) | 21.3 (1.1) | 20.7 (1.2) | 0.003 | 0.001 | |
| FAZ (circularity index) | 0.7 (0.1) | 0.7 (0.1) | 0.6 (0.1) | 0.102 | 0.031 | |
| RNFL (thinning, µm) | 6.3 (2.9) | 6.0 (2.8) | 6.0 (3.0) | 0.948 | 0.647 | |
| GCL-IPL (thinning, µm) | 82.0 (6.6) | 81.4 (6.1) | 81.7 (6.6) | 0.024 | 0.209 | |
| Full retina (thickening, µm) | 261.6 (25.2) | 261.7 (26.5) | 261.8 (26.2) | 0.742 | 0.660 | |
| ETDRS 35 (n = 17) | ||||||
| Vessel density, mm−1 | SCP | 19.4 (1.6) | 18.6 (2.1) | 17.9 (1.7) | 0.062 | 0.001 |
| DCP | 15.5 (2.1) | 14.8 (2.5) | 13.7 (2.3) | 0.028 | <0.001 | |
| FR | 21.4 (1.5) | 20.5 (2.0) | 20.0 (1.6) | 0.015 | 0.001 | |
| FAZ (circularity index) | 0.6 (0.1) | 0.6 (0.1) | 0.6 (0.1) | 0.089 | 0.754 | |
| RNFL (thinning, µm) | 7.1 (3.4) | 7.1 (3.9) | 6.0 (3.0) | 0.981 | 0.136 | |
| GCL-IPL (thinning, µm) | 76.2 (7.4) | 76.5 (6.7) | 76.5 (7.2) | 0.391 | 0.337 | |
| Full retina (thickening, µm) | 270.4 (30.1) | 270.5 (29.2) | 271.1 (29.9) | 0.226 | 0.115 | |
| ETDRS 43–47 (n = 9) | ||||||
| Vessel density, mm−1 | SCP | 19.5 (1.8) | 18.9 (1.6) | 17.9 (2.4) | 0.110 | 0.015 |
| DCP | 14.8 (2.9) | 14.1 (2.9) | 13.3 (2.6) | 0.173 | 0.066 | |
| FR | 21.1 (1.6) | 20.7 (1.6) | 19.5 (2.1) | 0.110 | 0.015 | |
| FAZ (circularity index) | 0.6 (0.1) | 0.6 (0.1) | 0.5 (0.1) | 0.953 | 0.069 | |
| RNFL (thinning, µm) | 6.3 (1.8) | 6.9 (2.4) | 6.7 (4.5) | 0.767 | 0.767 | |
| GCL-IPL (thinning, µm) | 81.3 (8.4) | 81.7 (8.2) | 81.7 (8.3) | 0.257 | 1.0 | |
| Full retina (thickening, µm) | 260.7 (27.0) | 262.7 (29.0) | 263.3 (28.5) | 0.372 | 0.169 | |
| All patients | ||||||
| Vessel density, mm−1 | SCP | 19.9 (1.5) | 19.0 (1.7) | 18.3 (1.8) | <0.001 | <0.001 |
| DCP | 15.6 (2.1) | 14.6 (2.4) | 13.7 (2.2) | <0.001 | <0.001 | |
| FR | 21.7 (1.3) | 20.9 (1.6) | 20.2 (1.6) | <0.001 | <0.001 | |
| FAZ (circularity index) | 0.6 (0.1) | 0.6 (0.1) | 0.6 (0.1) | 0.034 | 0.025 | |
| RNFL (thinning, µm) | 6.6 (2.9) | 6.6 (3.2) | 6.1 (3.3) | 0.944 | 0.294 | |
| GCL-IPL (thinning, µm) | 79.6 (7.6) | 79.6 (7.1) | 79.7 (7.5) | 0.628 | 0.884 | |
| Full retina (thickening, µm) | 264.8 (27.3) | 265.3 (27.7) | 265.7 (27.8) | 0.126 | 0.065 | |
* P value calculated by Wilcoxon signed-rank test. Values in bold indicate statistical significance.