Table 3.
Cox Regression and Competing Risk Regression Analyses with Death Due to UM Metastases as the Endpoint of Interest, Evaluating the Effect of Patient and Tumor Characteristics on Survival
| Univariable Cox Regression | Multivariable Cox Regression | Multivariable Competing Risks Regression | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristics | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P |
| A: Total Cohort (N = 583) | |||||||||
| Male gender | 0.84 | 0.64–1.1 | 0.21 | 2.19 | 1.25–3.86 | 0.006 | 1.91 | 1.08–3.36 | 0.03 |
| Age at enucleation | 1.03 | 1.02–1.04 | <0.001 | 1.03 | 1.01–1.05 | 0.01 | 1.02 | 0.99–1.04 | 0.12 |
| Largest basal diameter | 1.17 | 1.13–1.21 | <0.001 | 1.15 | 1.06–1.24 | <0.001 | 1.16 | 1.08–1.24 | <0.001 |
| Thickness | 1.08 | 1.03–1.13 | <0.001 | 0.93 | 0.84–1.02 | 0.1 | 0.93 | 0.84–1.03 | 0.17 |
| Mitotic count | 1.06 | 1.04–1.08 | <0.001 | 1.09 | 1.04–1.13 | <0.001 | 1.09 | 1.05–1.13 | <0.001 |
| Ciliary body involvement | 2.13 | 1.61–2.81 | <0.001 | 1.35 | 0.8–2.26 | 0.26 | 1.2 | 0.72–2.0 | 0.49 |
| Mixed/epithelioid cell type | 2.56 | 1.81–3.62 | <0.001 | 1.29 | 0.62–2.69 | 0.5 | 1.3 | 0.67– 2.54 | 0.44 |
| Extravascular matrix loops (known in 378 cases) | 2.95 | 1.89–4.63 | <0.001 | 2.13 | 0.99–4.55 | 0.05 | 2.28 | 1.08–4.8 | 0.03 |
| Extraocular growth | 2.17 | 1.53–3.07 | <0.001 | 2.76 | 1.54–4.94 | 0.001 | 2.73 | 1.59–4.7 | <0.001 |
| Monosomy 3 (known in 275 cases) | 5.42 | 3.26–9.01 | <0.001 | 1.74 | 0.8–3.77 | 0.16 | 1.51 | 0.72–3.13 | 0.27 |
| Gain of 8q (known in 245 cases) | 5.92 | 3.5–10.02 | <0.001 | 4.67 | 2.24–9.75 | <0.001 | 3.92 | 1.96–7.84 | <0.001 |
| B: After 5-Year Follow-Up (n = 297) | |||||||||
| Male gender | 0.99 | 0.57–1.69 | 0.94 | 6.21 | 0.56–69.04 | 0.14 | 6.87 | 1.26–37.42 | 0.03 |
| Age at enucleation | 1.03 | 1.0–1.05 | 0.03 | 1.04 | 0.96–1.11 | 0.34 | 1.03 | 0.95–1.11 | 0.46 |
| Largest basal diameter | 1.14 | 1.07–1.22 | <0.001 | 1.17 | 0.85–1.6 | 0.34 | 1.11 | 0.82–1.51 | 0.49 |
| Thickness | 1.09 | 1.0–1.18 | 0.05 | 0.84 | 0.6–1.19 | 0.33 | 0.87 | 0.52–1.47 | 0.61 |
| Mitotic count | 1.02 | 0.97–1.07 | 0.42 | 1.23 | 0.95–1.58 | 0.12 | 1.24 | 0.88–1.74 | 0.21 |
| Ciliary body involvement | 1.47 | 0.77–2.82 | 0.24 | 1.58 | 0.18–13.67 | 0.68 | 1.65 | 0.06–42.67 | 0.76 |
| Mixed/epithelioid cell type | 1.12 | 0.65–1.95 | 0.68 | 0.42 | 0.04–4.11 | 0.46 | 0.47 | 0.04–5.86 | 0.56 |
| Extravascular matrix loops (known in 176 cases) | 2.06 | 0.86–4.95 | 0.11 | 5.37 | 0.32–89.78 | 0.24 | 6.1 | 0.55–67.53 | 0.14 |
| Extraocular growth | 1.58 | 0.67–3.69 | 0.29 | 5.24 | 0.11–246.85 | 0.4 | 6.96 | 0.08–593.39 | 0.39 |
| Monosomy 3 (known in 113 cases) | 3.12 | 1.08–9.02 | 0.04 | 1.82 | 0.21–15.68 | 0.59 | 1.87 | 0.29–12.28 | 0.51 |
| Gain of 8q (known in 105 cases) | 10.31 | 2.23–47.74 | 0.003 | 15.1 | 1.69–135.07 | 0.02 | 14.75 | 1.77–122.99 | 0.01 |
Significant P values are in bold.