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. Author manuscript; available in PMC: 2020 Aug 4.
Published in final edited form as: J Biol Rhythms. 2020 Apr 14;35(3):287–301. doi: 10.1177/0748730420913672

Figure 5. Astrocytic modulation of the neuronal population with different intercellular signaling pathways removed.

Figure 5.

SCN models containing wild-type cells (no blockade), neurons unable to bind VIP (VIP_N), astrocytes unable to bind VIP (VIP_A), neurons unable to bind glutamate (Glu_N) or neurons unable to bind GABA (GABA_N) were constructed and simulated. (A) Average neuronal period (Mean±SEM) and percentage of rhythmic neurons (Mean±SEM). (B) Phase synchrony (Mean±SEM) and amplitude coherence (Mean±SEM) of the neuronal population. Note: simulation results for six experimentally-realized neuron/astrocyte mutations (Scenario 2–7 presented in Fig 2.) are shown in Fig. S4.