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. Author manuscript; available in PMC: 2020 Aug 4.
Published in final edited form as: J Biol Rhythms. 2020 Apr 14;35(3):287–301. doi: 10.1177/0748730420913672

Figure 6. Effect of increased network coupling strengths on the average period of the neuronal population.

Figure 6.

Model parameters for network coupling strengths associated with neuronal VIP (VIPR2_N) and glutamate (iGluRs) receptors and the glutamate synthesis/transport rate regulated by the astrocyte (EAATs) were increased from their nominal values. (A) Percentage increases in each parameter used to perform simulations of Scenario 2 (Wild-type neurons and Bmal1−/− astrocytes). (B) Period increases (Mean±SEM) of the simulated neuronal populations for Scenario 2. (C) Period increases (Mean±SEM) of the simulated neuronal populations for Scenario 4 (CK1ε Tau/+ neurons and CK1ε−/+ astrocytes) and simultaneous increases of VIP and glutamate receptor strengths.