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. 2020 Mar 9;61(3):8. doi: 10.1167/iovs.61.3.8

Figure 1.

Figure 1.

Inhibition of JAK/STAT or overexpression of miR-19b leads to suppression of phenotypes following induction AC in vivo. (A) Schematic image of establishing the AC)murine model and group treatments with the JAK/STAT inhibitor CYT387, miR-19b agomirs. The image also includes the control miR group. (B) Inflammatory scoring under slit lamp for 15 to 30 minutes following pollen challenge for clinical signs (redness, chemosis, discharge and tearing) from day 10 to day 14 following sensitization of the PBS, AC, AC + CYT387, AC + miR-19b, and AC + control miR groups. (C) Representative images of ocular symptoms under slit lamp for 15 to 30 minutes following the last challenge. (D) Conjunctival vascular permeability was measured by the Evans blue assay. (E) Representative images of eyes in each group following Evans blue injection. n = 6 mice for each group. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.