Figure 2.

Inhibition of the JAK/STAT pathway or overexpression of miR-19b leads to weakened inflammatory response in AC. (A) Histopathological representative images of hematoxylin and eosin staining of eyeball samples from mice of the PBS, AC, AC + CYT387, AC + miR-19b, and AC + control miR groups. The scale bars represent 200 µm (top) and 500 µm (bottom). (B) Cellular components and (C) eosinophilic granulocytes in the ocular surface tissue of mice in each group were quantified in number/mm². (D) Total serum IgE levels from mice in each group were measured by ELISA. The data are shown as the mean ± SD of three independent experiments and each experiment was performed in duplicate. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001.