Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jun 25;219(8):e202003038. doi: 10.1083/jcb.202003038

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Chastney et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — Overview of the proximity-dependent adhesome. (A) 16 adhesome proteins were selected as BioID baits, 14 of which were present in the consensus adhesome and span the four putative signaling axes of the PPI network (Horton et al., 2015). p130Cas (Bcar1) and GIT1 are present in the literature-curated adhesome (and the GIT1 homologue GIT2 is in the consensus adhesome; Zaidel-Bar et al., 2007). Baits are shown in orange, and edges represent evidence of PPIs. Thick gray borders indicate literature-curated adhesome proteins. Gene names are shown. Consensus adhesome components unconnected to the main network are not shown. (B) Pairwise comparisons of proximal proteins (BFDR ≤ 0.05) identified by each BioID bait are displayed as a heatmap. Protein names not matching the gene names in A are FAK, PTK; kindlin-2, FERMT2; palladin, PALLD; α-parvin, PARVA; paxillin, PXN; β-Pix, ARHGEF7; PINCH, LIMS1; ponsin, SORBS1; vinculin, VCL; and zyxin, ZYX. (C) GO enrichment analysis of the 147 proteins in the proximity-dependent adhesome. The top 10 overrepresented terms under the cellular component category are shown.