Table 3.

Multivariable analysis in patients with thyroid papillary adenocarcinoma.

Variables	Fine-Gray regression analysis			COX regression analysis
	P-value	HR	95% CI	P-value	HR	95% CI
Age	<0.0001	1.052	1.031–1.073	<0.0001	1.059	1.039–1.078
Sex
Male	Reference			Reference
Female	0.008	0.547	0.351–0.855	0.007	0.554	0.362–0.849
Marital status
Married	Reference			Reference
Unmarried	0.734	1.114	0.597–2.078	0.605	1.173	0.640–2.150
DSW	0.093	1.631	0.922–2.884	0.044	1.709	1.016–2.877
Stage
Localized	Reference			Reference
Regional	0.005	5.671	1.670–19.260	0.001	6.032	2.065–17.619
Distant	0.0004	10.217	2.822–36.982	<0.0001	11.762	3.909–35.390
Grade
Well differentiated	Reference			Reference
Moderately differentiated	0.685	1.153	0.579–2.298	0.693	1.145	0.584–2.246
Poorly differentiated	<0.0001	5.508	2.709–11.200	<0.0001	5.419	2.947–9.963
Undifferentiated	<0.0001	7.247	3.209–16.367	<0.0001	8.258	4.150–16.434
AJCC
I	Reference			Reference
II	0.366	2.185	0.402–11.878	0.336	2.051	0.474–8.865
III	0.384	0.598	0.188–1.900	0.247	0.513	0.166–1.587
IV	0.057	2.855	0.969–8.412	0.084	2.465	0.885–6.866
Radiation
Yes	Reference			Reference
No/unknown	0.007	2.035	1.220–3.395	0.004	1.998	1.247–3.203
Chemotherapy
Yes	Reference			Reference
No/unknown	<0.0001	0.181	0.087–0.375	<0.0001	0.199	0.107–0.370
Regional lymph nodes removal
Yes	Reference			Reference
No	0.657	1.148	0.623–2.117	0.846	1.057	0.604–1.850
Tumor size
1–10 mm	Reference			Reference
11–20 mm	0.040	2.627	1.045–6.605	0.045	2.697	1.023–7.110
21–40 mm	0.022	2.833	1.163–6.896	0.024	2.960	1.151–7.607
>40 mm	0.006	3.587	1.446–8.896	0.005	3.829	1.492–9.824

DSW – divorced, separated or widowed.