Table 2 –
Grade 2 toxicity estimatesa
| Timing | ||||||
|---|---|---|---|---|---|---|
| Acute | Late | |||||
| Grade 2 toxicity | Rate (%) | 95% CI (%) | Fraction | Rate (%) | 95% CI (%) | Fraction |
| Any GI toxicity | 1.8 | 0.9–3.3 | 10/551 | 3.6 | 2.2–5.6 | 20/551 |
| Diarrhea | 0.2 | 0–1.0 | 1/551 | 0.5 | 0.1–1.6 | 3/551 |
| GI hemorrhage | 0.2 | 0–1.0 | 1/551 | 2.2 | 1.1–3.8 | 12/551 |
| Hemorrhoids | 0.7 | 0.2–1.8 | 4/551 | 1.5 | 0.6–2.8 | 8/551 |
| Proctitis | 0.9 | 0.3–2.1 | 5/551 | 0.5 | 0.1–1.6 | 3/551 |
| Any GU toxicity | 10.2 | 7.8–13.0 | 56/551 | 22.7 | 19.3–26.4 | 125/551 |
| Cystitis | 0.9 | 0.3–2.1 | 5/551 | 0.4 | 0–1.3 | 2/551 |
| Frequency/urgency | 8.7 | 6.5–11.4 | 48/551 | 14.3 | 11.5–17.5 | 79/551 |
| Incontinence | 0.9 | 0.3–2.1 | 5/551 | 2.9 | 1.7–4.7 | 16/551 |
| GU hemorrhage | 0.0 | 0–0.7 | 0/551 | 2.0 | 1–3.5 | 11/551 |
| Retention | 2.2 | 1.1–3.8 | 12/551 | 8.7 | 6.5–11.4 | 48/551 |
| Urinary stricture | 0.5 | 0.1–1.6 | 3/551 | |||
CI = confidence interval; GI = gastrointestinal; GU = genitourinary.
a
Acute urinary stricture was not measured. Fifty-six patients had any grade 2 GU acute toxicity, but one of these patients also had Grade 3 toxicity. Therefore, 55 patients had a maximum grade of 2. Twenty patients had any grade 2 GI late toxicity, but one of these patients also had grade 3 toxicity. Therefore, 19 patients had a maximum grade of 2.