Table 3 –
Toxicity proportions by maximum gradea
| Timing, n (%) | ||||||
|---|---|---|---|---|---|---|
| Acute | Late | |||||
| Grade 1 | Grade 2 | Grades 3–5 | Grade 1 | Grade 2 | Grades 3–5 | |
| Any GI toxicity | 55 (10) | 10 (1.8) | 0 (0) | 100 (18.1) | 19 (3.4) | 2 (0.4) |
| Diarrhea | 20 (3.6) | 1 (0.2) | 28 (5.1) | 3 (0.5) | ||
| GI hemorrhage | 17 (3.1) | 1 (0.2) | 0 (0) | 34 (6.2) | 12 (2.2) | 2 (0.4) |
| Hemorrhoids | 31 (5.6) | 4 (0.7) | 72 (13.1) | 8 (1.5) | ||
| Proctitis | 6 (1.1) | 5 (0.9) | 3 (0.5) | 3 (0.5) | ||
| Any GU toxicity | 173 (31.4) | 55 (10) | 4 (0.7) | 196 (35.6) | 116 (21.1) | 14 (2.5) |
| Cystitis | 21 (3.8) | 5 (0.9) | 2 (0.4) | 2 (0.4) | ||
| Frequency/urgency | 160 (29) | 48 (8.7) | 2 (0.4) | 211 (38.3) | 79 (14.3) | 8 (1.5) |
| GU hemorrhage | 9 (1.6) | 0 (0) | 0 (0) | 28 (5.1) | 11 (2) | 2 (0.4) |
| Incontinence | 29 (5.3) | 5 (0.9) | 0 (0) | 61 (11.1) | 16 (2.9) | 3 (0.5) |
| Retention | 42 (7.6) | 12 (2.2) | 2 (0.4) | 98 (17.8) | 48 (8.7) | 4 (0.7) |
| Urinary stricture | 3 (0.5) | |||||
GI = gastrointestinal; GU = genitourinary.
a
Numbers in parentheses represent frequency with percent of total. Acute urinary stricture was not measured. Fifty-six patients had any grade 2 GU acute toxicity, but one of these patients also had grade 3 toxicity. Therefore, 55 patients had a maximum grade of 2. Twenty patients had any grade 2 GI late toxicity, but one of these patients also had grade 3 toxicity. Therefore, 19 patients had a maximum grade of 2.