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. 2020 Jul 9;9(7):599. doi: 10.3390/antiox9070599

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of Tubastatin A on retinal histopathology and vascular leakage. (A) Hematoxylin and eosin (H&E) staining of retinal cryosections assessing retinal morphology of STZ-rats (DB), STZ-rats receiving TS (10 mg/kg) (DB + TS) and normoglycemic control rats (control). Scale bar, 50 µm. (B) The bars represent retinal thickness values measured in H&E retinal cryosections obtained from the different treatment groups. (C) Western analysis of albumin extravasation in retinas of diabetic STZ-rats (DB), STZ-rats receiving 10 mg/kg TS (DB + TS) and normoglycemic control rats (control). (D) Bar histograms representing optical density of albumin normalized to actin. Values are mean ± SEM for n = 6. * p < 0.05 vs. control and ^# p < 0.05 vs. DB.