Supplementary Table 1.

Spore-Forming Bacterial Taxa Identified in SER-287 Lots

Phylum	Class	Order	Family	Genus	Drug lots, n
Firmicutes	Clostridia	Clostridiales	Christensenellaceae	Unclassified Christensenellaceae	2
			Clostridiaceae	Clostridium	3
			Eubacteriaceae	Anaerofustis, Eubacterium	1
				[Eubacterium]	2
			Lachnospiraceae	Acetatifactor, Coprococcus	1
				Desulfotomaculum	2
				[Clostridium], [Coprococcus], [Eubacterium], [Faecalicatena], [Ruminococcus], Anaerostipes, Blautia, Dorea, Eisenbergiella, Fusicatenibacter, Lachnospira, unclassified Lachnospiraceae, Lactonifactor, Marvinbryantia, Roseburia	3
			Peptostreptococcaceae	Intestinibacter	3
			Ruminococcaceae	Harryflintia	1
				[Clostridium], [Ruminococcus], Agathobaculum, Faecalibacterium, Fusicatenibacter, Gemmiger, Massilimaliae, unclassified Ruminococcaceae, Ruminococcus, Subdoligranulum	3
	Erysipelotrichia	Erysipelotrichales	Erysipelotrichaceae	Catenibacterium, Holdemanella, Solobacterium	1
				Erysipelatoclostridium	2
				[Clostridium], Holdemania, Turicibacter	3

NOTE. The 3 lots of SER-287 that were used in the clinical trial were characterized by direct whole metagenomic shotgun sequencing. The list of genera with spore-forming species identified in any of the 3 lots is indicated; bracketed genera are pending reassignment in National Center for Biotechnology Information taxonomy (https://www.ncbi.nlm.nih.gov/taxonomy); unclassified family names within the genera column indicate species without genus assignments. Rows in the table are organized according to the hierarchical taxonomy. The last column indicates the number of drug lots in which the genera were identified.