Supplementary Table 7.

Change in Microbiome Composition (β-Diversity) Post-Treatment Compared With Placebo

Treatment group compared with placebo/placebo	Days post treatment	P value (unadjusted)	Placebo/placebo mean	Treatment group mean
Placebo/SER-287 weekly	0	.769	0.330	0.329
	3	.701	0.317	0.296
	7	.469	0.288	0.339
	10	.871	0.265	0.354
	14	.733	0.326	0.342
	56	.517	0.340	0.400
	84	.626	0.421	0.443
Vancomycin/SER-287 daily	0	.003	0.330	0.865
	3	.001	0.317	0.775
	7	.001	0.288	0.747
	10	.001	0.265	0.663
	14	.001	0.326	0.672
	56	.002	0.340	0.650
	84	.067	0.421	0.680
Vancomycin/SER-287 weekly	0	.002	0.330	0.906
	3	<.001	0.317	0.841
	7	<.001	0.288	0.775
	10	.001	0.265	0.718
	14	<.001	0.326	0.654
	56	.001	0.340	0.601
	84	.092	0.421	0.606

NOTE. β-diversity distance (binary Jaccard) from baseline for subjects in each treatment group at the given time point, compared with placebo. P value indicates 2-sided Mann Whitney U test for the indicated treatment arm compared with placebo. See Supplementary Table 2 for the number of subjects.