Table 1.
Characteristic | Non-MIS-C, n (%) | MIS-C, n (%) | Total, n (%) |
---|---|---|---|
Total | 69 (100) | 10 (100) | 79 (100) |
Age, median (IQR), y | 4 (1−10.5) | 5.2 (1.5−8.4) | 4 (1−10.3) |
Infants (<12 m) | 17 (25) | 2 (20) | 19 (24) |
Toddler (≥12 m, <3 y) | 16 (23) | 2 (20) | 18 (23) |
Preschool (≥3 y, <5 y) | 6 (9) | 1 (10) | 7 (9) |
Grade-schooler (≥5 y, <12 y) | 15 (22) | 4 (40) | 19 (24) |
Adolescent (≥12 y, <18 y) | 13 (19) | 1 (10) | 14 (18) |
Young adult (≥18 y) | 2 (3) | 0 (0) | 2 (3) |
Sex | |||
Male | 35 (51) | 8 (80) | 43 (54) |
Female | 34 (49) | 2 (20) | 36 (46) |
Race/ethnicity | |||
White | 40 (58) | 6 (60) | 46 (58) |
Mixed race/ethnicity | 19 (28) | 1 (10) | 20 (25) |
Black | 10 (14) | 2 (20) | 12 (15) |
Asian | 0 (0) | 1 (10) | 1 (1) |
Comorbidities | 30 (43) | 2 (20) | 32 (41) |
Neuromuscular diseasea | 9 (30) | 1 (50) | 10 (31)c |
Chronic respiratory diseaseb | 6 (20) | – | 6 (19)c |
Oncohematological disease | 6 (20) | – | 6 (19)c |
Congenital heart defect | 4 (13) | 1 (50) | 5 (16)c |
Undernutrition | 4 (13) | – | 4 (13)c |
Diabetes | 2 (7) | – | 2 (6)c |
Prematurity | 2 (7) | – | 2 (6)c |
Chronic liver disease | 1 (3) | – | 1 (3)c |
Obesity | 1 (3) | – | 1 (3)c |
Contact with a suspected case (n = 31) | 24 (35) | 31 (39) | |
Household | 20 (83) | 7 | 27 (87) |
Other | 4 (17) | 3 | 4 (13) |
Main clinical syndrome at presentation | |||
Respiratoryd | 47 (68) | 47 (60) | |
MIS | – | 10 (100) | 10 (13) |
Kawasaki-like disease | – | 6 (60) | 6 (60) |
Acute cardiac dysfunction | – | 2 (20) | 2 (20) |
Toxic shock syndrome | – | 1 (10) | 1 (10) |
Macrophage activation syndrome | – | 1 (10) | 1 (10) |
Othere | 22 (32) | – | 22 (28) |
Symptoms before hospitalization, median (IQR), days | 5 (2−8) | 2 (1−3) | 4 (2−8) |
Clinical features at presentation | |||
Fever | 51 (75) | 8 (80) | 59 (76) |
Cough | 36 (53) | 4 (40) | 40 (51) |
Tachypnea | 33 (49) | 6 (60) | 39 (50) |
Low SpO2 (<92%) | 19 (28) | 4 (40) | 23 (29) |
Prostration | 13 (19) | 6 (60) | 19 (24) |
Chest retraction | 17 (25) | 1 (10) | 18 (23) |
Runny nose | 16 (24) | 1 (10) | 17 (22) |
Diarrhea | 12 (18) | 4 (40) | 16 (21) |
Feed refusal | 11 (16) | 5 (50) | 16 (21) |
Vomiting | 10 (15) | 6 (60) | 16 (21) |
Dehydration | 9 (13) | 4 (40) | 13 (17) |
Nasal flaring | 6 (9) | 2 (20) | 8 (10) |
Groaning | 4 (6) | 3 (30) | 7 (9) |
Cyanosis | 4 (6) | 1 (10) | 5 (6) |
Hypotension | 3 (4) | 2 (20) | 5 (6) |
Red throat | 2 (3) | 1 (10) | 3 (4) |
COVID-19, coronavirus disease 2019; IQR, interquartile range; MIS-C, multisystemic inflammatory syndrome in children; PICU, pediatric intensive care unit; SpO2, pulse oximeter oxygen saturation.
Non-progressive encephalopathy (n = 7), other causes (n = 2).
Asthma (n = 3), bronchopulmonary dysplasia (n = 1), tracheomalacia (n = 1), other (n = 3)d.
Some patients presented more than one comorbidity.
Pneumonia, 23; bronchiolitis, 10; other, 14.
Gastrointestinal, 8; neurological, 4; miscellaneous, 10.