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. 2020 Jun 30;9(7):566. doi: 10.3390/antiox9070566

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Honey extracts inhibit the UVB-induced expression of MMPs in a 3D reconstituted human skin model (Epiderm^TM EPI-200). Tissues were pre-treated with 20 μg/mL of honey extracts ME16.1 or ME20.3 for 2 h, followed by UVB irradiation (55 mJ/cm²) and then incubation with honey extracts for 2 h. After 24 h, the tissues were harvested, sections were taken and immunostaining was performed to detect UVB-induced MMP-1 (A–D), MMP-3 (E–H), MMP-7 (I–L) and MMP-9 (M–P) positive cells. Representative images at 400× magnification of untreated (A,E,I,M), UVB-irradiated (B,F,J,N), ME16.1 pre-treated/UVB-irradiated (C,G,K,O) and ME20.3 pre-treated/UVB-irradiated (D,H,L,P) tissues.