Table 1.
Hydrodynamic diameter (d), polydispersity index (PDI), surface charge, drug association (DA) and association efficiency (AE) of blank and drug-associated P68 + DQA nanoformulations prepared at 80 °C (mean ± S.D., n = 6).
| Sample | Contents | d (nm) | PDI | Charge (mV) | DA (%) | AE (%) | |
|---|---|---|---|---|---|---|---|
| P68 + DQA (Blank) | P68: | 9 mg/mL | 25.52 ± 10.25 | 0.24 ± 0.04 | −0.78 ± 0.80 | - | - |
| DQA: | 1 mg/mL | ||||||
| P68 + DQA NAC | P68: | 9 mg/mL | 125.67 ± 9.98 | 0.23 ± 0.05 | 3.67 ± 0.46 | 64.88 ± 1.93 | 92.74 ± 7.54 |
| DQA: NAC: |
1 mg/mL 20 mg/mL |
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| P68 + DQA NAC + DFO |
P68: | 9 mg/mL | 130.33 ± 11.49 | 0.24 ± 0.02 | 6.63 ± 1.44 | NAC: 17.53 ± 0.56 DFO: 17.59 ± 0.54 |
NAC: 98.32 ± 1.44 DFO: 94.36 ± 4.27 |
| DQA: NAC: DFO: |
1 mg/mL 12.4 mg/mL 5 mg/mL |
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