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. 2020 Jul 17;9(7):631. doi: 10.3390/antiox9070631

Figure 1.

Figure 1

A simplified diagram of the signaling pathways of apoptosis. Akt (protein kinase B); ASK1 (apoptosis signal-regulating kinase 1); Apaf-1 (apoptotic protease activating factor 1); Bad (Bcl-2-associated death promoter); Bak (Bcl-2 homologous antagonist killer); Bax (Bcl-2-associated X protein); DISC (death-inducing signaling complex); ERK1/2 (extracellular signal-regulated kinases, 1 and 2 isoforms); JNK (c-Jun NH2-terminal kinases); p90RSK (p90 ribosomal S6 kinase); PI3K (phosphatidylinositol 3-kinase); PIP3 (phosphatidylinositol trisphosphate); PKCα (protein kinase C α); PP2A (protein phosphatase 2A); TNF-α (tumour necrosis factor α); TNFR (tumour necrosis factor receptor); ROS (reactive oxygen species); (activation); (inhibition). Compounds in yellow boxes are inhibitors.