Figure 1.

The expression of glutathione S-transferase omega 2 (GstO2) resulted in alterations of human transactive response DNA-binding protein-43 (hTDP-43)-induced retinal degeneration. Magnified images show pigment loss of each genotype. The external eye phenotypes of GMR-Gal4 control flies and flies expressing GstO2 alone were normal. The overexpression of hTDP-43 with the GMR-Gal4 driver induced a rough eye phenotype, including the consistent loss of eye pigmentation. The degeneration of the external eye phenotype was rescued by the co-expression of hTDP-43 with GstO2. Quantification of pigment loss in the selected area (magnified view) for each genotype was performed by ImageJ software and normalized to the value of the GMR-Gal4 control flies. Statistical significance was determined using the unpaired Student t-test (*** p < 0.001, n = 10 for each genotypes). Error bars indicate the standard error of the mean (SEM).