Figure 6.

Expression of the H₂S-producing enzymes in th ePBMCs from multiple sclerosis (MS) patients. The expression levels of Mercaptopyruvate Sulfurtransferase (MPST) (A), Cystathionine Beta-Synthase (CBS) (B), and Cystathionine Gamma-Lyase (CTH) (C) were evaluated in the PBMCs from healthy donors and drug-naïve relapse-remitting MS patients, by interrogating the publicly available GSE138064 dataset, retrieved from the GEO database (https://www.ncbi.nlm.nih.gov/gds [48]). Data are shown in log2 scale. (D) Correlation between the MPST expression and the cytokines, the immune-activation markers (E) and the anti-inflammatory enzymes expression (F), as determined in the GSE138064 dataset. The deconvolution analysis of the immune cells in the PBMCs from healthy donors and MS patients, as determined in the GSE138064 dataset, is presented as the heatmap of the cell enrichment (G) and correlation (H) analysis.* FDR < 0.05; ** FDR < 0.01; *** FDR < 0.001.