Fine motor milestone acquisition by genotype. Age at developmental skill acquisition was determined for the 5 most prevalent genotypes, IFIH1, TREX1, RNASEH2B, SAMHD1, andADAR, as presented with Kaplan-Meiercurves. P-values were calculated using the Log-rank(Mantel-Cox)test comparing genotypes and is designated as * for p<0.05, ** for p < 0.01, and *** for p < 0.005.