Social and language milestone acquisition by genotype. Age at developmental skillacquisitionwasdeterminedforthe5mostprevalentgenotypes, IFIH1,TREX1, RNASEH2B,SAMHD1, andADAR, as presented with Kaplan-Meiercurves. P-values were calculated using the Log-rank(Mantel-Cox)test comparing genotypes and is designated as * for p<0.05, ** for p < 0.01, and *** for p < 0.005.