Table 1.
Summary of diagnostic performances of elastography reported in meta-analyses.
| Elastography | Etiology | F2 | F3 | F4 | Reference | |
|---|---|---|---|---|---|---|
| One-dimensional Ultrasound (Transient elastography) | Various etiologies | Cutoff (kPa) | 7.65 | N/A | 13.01 | [10] |
| Sensitivity | N/A | N/A | N/A | |||
| Specificity | N/A | N/A | N/A | |||
| AUROC | 0.84 | 0.89 | 0.94 | |||
| HBV | Cutoff (kPa) | 7.9 | 8.8 | 11.7 | [11] | |
| Sensitivity | 74.3 | 74.0 | 84.6 | |||
| Specificity | 78.3 | 63.8 | 81.5 | |||
| AUROC | 0.859 | 0.887 | 0.929 | |||
| Point shear wave Ultrasound |
Various etiologies | Cutoff (m/s) | 1.31 | N/A | 1.80 | [12] |
| Sensitivity | 74 | N/A | 87 | |||
| Specificity | 83 | N/A | 87 | |||
| AUROC | 0.85 | N/A | 0.93 | |||
| Nonviral | Cutoff (m/s) | N/A | N/A | N/A | [13] | |
| Sensitivity | 79 | 92 | 89 | |||
| Specificity | 81 | 85 | 89 | |||
| AUROC | 0.87 | 0.94 | ||||
| Two dimensional Ultrasound |
HCV | Cutoff (kPa) | 7.1 | 9.2 | 13.0 | [14] |
| Sensitivity | 94.7 | 90.3 | 85.8 | |||
| Specificity | 52.0 | 76.8 | 87.8 | |||
| AUROC | 0.863 | 0.915 | 0.929 | |||
| HBV | Cutoff (kPa) | 7.1 | 8.1 | 11.5 | ||
| Sensitivity | 87.6 | 94.9 | 79.9 | |||
| Specificity | 73.6 | 73.1 | 93.3 | |||
| AUROC | 0.906 | 0.931 | 0.955 | |||
| NAFLD | Cutoff (kPa) | 7.1 | 9.2 | 13.0 | ||
| Sensitivity | 93.8 | 93.1 | 75.3 | |||
| Specificity | 52.0 | 80.9 | 87.8 | |||
| AUROC | 0.855 | 0.928 | 0.917 | |||
| Others | Cutoff (kPa) | 7.1 | 9.2 | 13.0 | ||
| Sensitivity | 94.8 | 95.1 | 79.4 | |||
| Specificity | 39.9 | 86.6 | 83.6 | |||
| AUROC | N/A | N/A | N/A | |||
| MRI elastography | Various etiologies | Cutoff (kPa) | 3.66 | 4.11 | 4.71 | [15] |
| Sensitivity | 79 | 85 | 91 | |||
| Specificity | 81 | 85 | 81 | |||
| AUROC | 0.88 | 0.93 | 0.92 |
Abbreviations: MRI, magnetic resonance imaging; HBV, hepatitis B virus; HCV, hepatitis C virus; NAFLD, nonalcoholic fatty liver disease; AUROC, area under the receiver operating characteristic; F, fibrosis stage; N/A, not available.