Table 3.
Serum tests and their diagnostic performances.
| Factors | Etiology | F2 | F3 | F4 | Reference | ||
|---|---|---|---|---|---|---|---|
| FibroTest | α2-macroglobulin, haptoglobin, GGT, γ-globulin, total bilirubin, and apolipoprotein A1 | HCV | AUROC | 0.66 | 0.66 | 0.66 | [30] |
| HBV | AUROC | 0.63 | 0.78 | 0.54 | |||
| ALD | AUROC | 0.65 | 0.66 | 0.82 | |||
| NAFLD | AUROC | 0.69 | 0.69 | 0.71 | |||
| APRI | AST, platelet count | HCV | Cutoff | 0.7 | 1.0 | 2.0 | [31] |
| Sensitivity | 77 | 61 | 46 | ||||
| Specificity | 72 | 64 | 91 | ||||
| AUROC | 0.77 | 0.80 | 0.83 | ||||
| HBV | Cutoff | 0.5 | 1.0 | 1.5 | [32] | ||
| Sensitivity | 70 | 50 | 36.9 | ||||
| Specificity | 60 | 83 | 92.5 | ||||
| AUROC | 0.72 | 0.76 | 0.72 | ||||
| FIB-4 Index | Age, AST, ALT, platelet count | HCV | Cutoff | 3.25 | [33] (single study) | ||
| Sensitivity | 23 | ||||||
| Specificity | 97 | ||||||
| AUROC | 0.737 | ||||||
| HBV | Cutoff | 0.8–1.085 | 1.45–1.65 | 2.9–3.6 | [34] | ||
| Sensitivity | 73 | 68 | 42 | ||||
| Specificity | 62 | 75 | 96 | ||||
| AUROC | 0.73 | 0.77 | 0.96 | ||||
| M2BPGi | Various etiology | Cutoff | 0.90–1.42 | 0.94–3.70 | 1.26–4.62 | [35] | |
| Sensitivity | 69 | 76 | 82 | ||||
| Specificity | 78 | 76 | 84 | ||||
| AUROC | N/A | N/A | N/A |
Abbreviations: Ref, reference; GGT, gamma-glutamyl transferase; HCV, hepatitis C virus; HBV, hepatitis B virus; ALD, alcoholic liver disease; NAFLD, nonalcoholic fatty liver disease; AUROC, area under the receiver characteristic; F, fibrosis stage; APRI, aspartate transaminase to platelet ratio index; AST, aspartate aminotransferase; ALT, alanine aminotransferase; M2BPGi, Mac-2 binding protein glycosylation isomer; N/A, not available.