Table 5.

Summary of tissue inhibitors of metalloproteinase.

TIMP Classification	Pathology	References
TIMP1	Inhibition of collagenase Inhibition of activation of pro-MMPs Inhibition of programmed cell death of HSCs	[104,105,106,107,108,109,110,111]
TIMP2	Inhibition of MT1-MMP, MMP-2 Activation of pro-MMP2	[112,113,114,115,116]
TIMP3	Promotion of apoptosis Regulation of inflammation through inhibition of ADAM17	[117]
TIMP4	Inhibition of MT1-MMP	[118]

Abbreviation: MMP, matrix metalloproteinase; HSC, hepatic stellate cell; MT. membrane type; ADAM17, a disintegrin and metalloproteinase 17.