Schematic representation of the different pathways activated by the natural compounds that are involved in Nrf2 modulation. The orange ovals indicate the compounds that activated each pathway. The figure was made taking the images from Servier Medical Art (available at http://smart.servier.com/), licensed under a Creative Commons Attribution 3.0 Unported License (https://creativecommons.org/licenses/by/3.0/). AMPK, monophosphate-activated protein kinase; BACH1, BTB domain and CNC homolog 1; EGCG, (-)-Epigallocatechin-3-gallate; ERK, extracellular signal-related kinase; GA, Ginkgolides A; GB, Ginkgolides B; GC, Ginkgolides C; GAS, gastrodin; Keap1, Kelch- like ECH- associated protein 1; LyA, Lyciumamide A; Maf, musculoaponeurotic fibrosarcoma oncogene homologue; miRNA, Nef, Neferine; Nrf2, Nuclear factor erythroid 2-related factor 2; PCA, protocatechualdehyde; PI3K, phosphoinositide 3-kinases; PKC, protein kinase C; RA, rosmarinic acid; Rg1, Ginsenoside Rg1; Sch A, Schizandrin A; Swe, Swertiamarin; THSWD, Tao Hong Si Wu decoction.