Table 1.
Respiratory parameters in control and chronic intermittent hypoxia animals and the effect of chronic domperidone treatment. The table shows breathing frequency, tidal volume and minute volume from the four group of animals breathing at different atmospheres. Data are mean and SD of eight individual values in each group. In the upper part control (C) and control with DOM (CD; 15 days with 0.75 mg/day of DOM treatment). In the lower part the same respiratory parameters from animals exposed to intermittent hypoxia during 30 days (CIH) and CIH treated with DOM (CIHD; 0.75 mg/day during 15 days). Two-way ANOVA showed no statistical differences among groups.
| Animals | C | CD | ||||
|
Respiratory
Parameter |
Breathing Frequency
(Breaths min−1) |
Tidal Volume
(mL kg−1) |
Minute Ventilation
(mL min−1 kg−1) |
Breathing Frequency
(Breaths min−1) |
Tidal Volume
(mL kg−1) |
Minute Ventilation
(mL min−1 kg−1) |
| 21% O2 (air) | 129 (93) | 4.6 (0.5) | 532 (288) | 114 (47) | 5.4 (0.5) | 564 (178) |
| 12% O2 | 131 (23) | 5.4 (0.7) | 664 (45) | 160 (17) | 5.7 (0.7) | 809 (178) |
| 10% O2 | 139 (30) | 5.1 (0,7) | 921 (100) | 134 (26) | 6.2 (0.6) | 951 (89) |
| 7% O2 | 139 (30) | 8.0 (0.8) | 1066 (201) | 134 (26) | 8.6 (0.8) | 1110 (138) |
| 5% CO2 in air | 150 (24) | 7.9 (0.8) | 1151 (136) | 141 (30) | 7.6 (0.8) | 1041 (200) |
| Animals | CIH | CIHD | ||||
|
Respiratory
Parameter |
Breathing Frequency
(Breaths min−1) |
Tidal Volume
(mL kg−1) |
Minute Ventilation
(mL min−1 kg−1) |
Breathing Frequency
(Breaths min−1) |
Tidal Volume
(mL kg−1) |
Minute Ventilation
(mL min−1 kg−1) |
| 21% O2 (air) | 92 (31) | 4.9 (0.5) | 409 (82) | 93 (28) | 5.0 (0.9) | 418 (68) |
| 12% O2 | 124 (17) | 5.3 (0.7) | 622 (74) | 119 (17) | 5.4 (0.7) | 624 (106) |
| 10% O2 | 152 (28) | 6.1 (0.8) | 851 (156) | 147 (16) | 6.4 (1.0) | 892 (81) |
| 7% O2 | 121 (12) | 7,6 (1.1) | 886 (126) | 123 (18) | 7.9 (1.1) | 953 (182) |
| 5% CO2 in air | 130 (66) | 5.2 (0.6) | 969 (97) | 132 (17) | 7.6 (1.0) | 984 (152) |