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Immune Checkpoint Molecule and Immune Checkpoint Inhibitor. (a) The combination of common immune checkpoint molecules and their ligands. (b) Simplified illustration of the immune checkpoint inhibitor mechanism. CTLA-4, Cytotoxic T-Lymphocyte Associated Protein 4; PD-1, Programed cell death 1; LAG-3, Lymphocyte Activating 3; TIM-3, T-cell immunoglobulin mucin-3; Gal-9, galectin-9; ICI, Immune checkpoint inhibitor; APC, antigen-presenting cell.
