Table 1.
Polymorphisms (non-HLA genes) associated with rheumatoid arthritis (RA) in mixed populations according to meta-analyses data.
| Protein Product | Gene | Polymorphism | Allele/Genotype Associated with RA | Reference |
|---|---|---|---|---|
| Protein tyrosine phosphatase, nonreceptor type 22 | PTPN22 | rs2476601 rs2488457 |
T C |
[30,31,32,36] |
| Peptidyl arginine deiminase 4 | PADI4 | rs11203367 rs884871 rs2240340 |
T G A |
[37] |
| Tumor necrosis factor, alpha-induced protein 3 (A20) | TNFAIP3 | rs2230926 rs5029937 |
G T |
[28] |
| Cytotoxic T-lymphocyte associated protein 4 | CTLA4 | rs231775 | GG | [38] |
| Signal transducer and activator of transcription 4 | STAT4 | rs7574865 | T | [29] |
| C-C motif chemokine receptor 6 | CCR6 | rs3093024 | A | [24] |
| C-C motif chemokine ligand 2 (monocytes chemo-attractant) | CCL2 | rs1024611 | G | [39] |
| Autoimmune regulator (transcription factor) | AIRE | rs2075876 rs760426 |
A G |
[35] |
| Methylene tetrahydrofolate reductase | MTHFR | rs1801133 rs1801131 |
T CC |
[40,41] |
| Interleukin 10 | IL10 | rs1800896 rs3021097 rs1800872 |
AA TT AA |
[42] |
| Interleukin 23 receptor | IL23R | rs11209026 rs10489629 rs1343151 |
AA G A |
[23,43] |
| Interleukin 17 | IL17 | rs2275913 | AA | [44] |
| Tumour necrosis factor receptor type 2 | TNFR2 | rs1061622 | GG | [45] |
| Transforming growth factor beta and its receptors | TGFB | rs1800470 rs1800469 |
TT TT |
[46] |