Table 5.

(A) Gene ontology (GO) biologic process (20 most dysregulated GO-term); (B) KEGG pathways and (C) reactome pathways of the 18 common dysregulated genes (analyzed by String 11.1 Database).

(A) GO-term	Description	Count in Gene Set	False Discovery Rate
GO:0071346	cellular response to interferon-gamma	2 of 39	0.0265
GO:0070098	chemokine-mediated signaling pathway	2 of 30	0.0265
GO:0050921	positive regulation of chemotaxis	2 of 68	0.0265
GO:0048522	positive regulation of cellular process	7 of 2201	0.0265
GO:0048247	lymphocyte chemotaxis	2 of 20	0.0265
GO:0045087	innate immune response	3 of 217	0.0265
GO:0044089	positive regulation of cellular component biogenesis	3 of 220	0.0265
GO:0040011	locomotion	4 of 404	0.0265
GO:0030593	neutrophil chemotaxis	2 of 23	0.0265
GO:0016477	cell migration	3 of 293	0.0265
GO:0010469	regulation of signaling receptor activity	4 of 325	0.0265
GO:0009967	positive regulation of signal transduction	4 of 638	0.0265
GO:0006955	immune response	4 of 386	0.0265
GO:0006954	inflammatory response	3 of 250	0.0265
GO:0006935	chemotaxis	3 of 172	0.0265
GO:0006928	movement of cell or subcellular component	4 of 486	0.0265
GO:0002687	positive regulation of leukocyte migration	2 of 63	0.0265
GO:0002548	monocyte chemotaxis	2 of 12	0.0265
GO:0071347	cellular response to interleukin-1	2 of 75	0.0267
GO:0051173	positive regulation of nitrogen compound metabolic process	5 of 1184	0.0267
(B) KEGG Pathways	Pathway Description	Count in Gene Set	False Discovery Rate
rno04060	Cytokine–cytokine receptor interaction	3 of 217	0.0130
(C) Reactome Pathways	Pathway Description	Count in Gene Set	False Discovery Rate
RNO-68877	Mitotic prometaphase	4 of 168	0.00063
RNO-5663220	RHO GTPases activate formins	3 of 116	0.0013
RNO-2500257	Resolution of sister chromatid cohesion	3 of 100	0.0013
RNO-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	3 of 80	0.0013
RNO-2467813	Separation of sister chromatids	3 of 149	0.0019