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. 2020 Jul 9;21(14):4869. doi: 10.3390/ijms21144869

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Trp73^D13/D13 mice display hippocampal dysgenesis and CR cells depletion. (A) Immunohistochemistry of postnatal day 5 (P5) mouse hippocampus displays disrupted morphology and reduced presence of Reelin+ CR cells in Trp73^D13/D13 genotype. Scale bars indicate 500 µm and 50 m.(B) Representative summary of morphological developmental progression in the hippocampus of Trp73+/+ and Trp73^D13/D13 from embryonic 16.5 (E16.5) to postnatal day 20 (P20) stage. Adapted with modifications from Amelio et al. [162].