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. 2020 Aug 4;15(8):e0235930. doi: 10.1371/journal.pone.0235930

Fig 11. Two circadian oscillator networks with different molecular clockworks control locomotor activity rhythms of the Madeira cockroach.

Fig 11

The lead oscillator network (LeON) with a shorter period and the lag oscillator network (LaON) with a longer period, each consist of four single oscillator neurons. In LeON only PERIOD (PER) constitutes the negative limb of the core transcriptional feedback loop in all of the circadian pacemaker neurons. However, in LaON two different cell types exist, one with PER and CRYPTOCHROME 2 (CRY2), and the other with TIMELESS1 (TIM1) as transcriptional repressors.