Table 1. Periods (τ)of free-running locomotor activity rhythms.

τ / h ± SD; number
dsRNA	1–7 days before injection	3–4 weeks after injection	Difference / after–before injection#
gfp (control)	23.42 ± 1.64; 13	23.61 ± 1.82; 10	0.22 ± 1.80
Rm’per	23.59 ± 0.81; 12	24.32 ± 0.93; 8	0.76 ± 0.93
Rm’tim1	23.36 ± 1.92; 10	19.42 ± 0.63; 8‡	-3.82 ± 2.17‡
Rm’cry2	23.79 ± 0.44; 20	20.98 ± 1.61; 14‡	-2.83 ± 1.69‡

^# only animals with determinable period after injection were included.

^† period differed highly significantly between evaluated time intervals before and after injection; Rm’tim1: p = 0.0016; Rm’cry2: p<0.0001, paired Student’s t-test.

^‡ period differed highly significantly from gfp control dsRNA injected animals; Rm’tim1: p = 0.0005, Rm’cry2: p = 0.0003, Student’s t-test.