Fig 1. Effect of HF-induced electrical remodelling on the APD₉₀, CaT amplitude and SR Ca²⁺ content.

(Ai), (Bi) and (Ci) Recordings of APs, intracellular Ca²⁺ concentration ([Ca²⁺]_i) and Ca²⁺ concentration in NSR ([Ca²⁺]_NSR) under control and HF conditions at 1Hz. (Aii) and (Bii) The increased APD₉₀ (ΔAPD₉₀) and increased CaT amplitude (ΔCaT amplitude) under HF conditions relative to control from experimental data [18] (grey and black) and simulations (while) at 1 Hz and 2Hz. (Cii) The increased SR Ca²⁺ content (ΔSR Ca²⁺ content) in HF relative to the control from experimental data [18] (grey and black) and simulations (while) at 1 Hz.