Table 6.

Mortality outcome within subgroups of annualised FVC change for various visual CT variables

FVC decline range	Categorical change in visual CT variables	Visual CT variables (HR, 95% CI, P value, Concordance Index)	FVC decline (HR, 95% CI, P value)
FVC 5.0%–9.9% decline	Total ILD extent	3.09, 1.39 to 6.88, 0.03, 0.69	1.85, 0.04 to 78.77, 0.74
	Ground-glass opacity extent	2.36, 1.04 to 5.35, 0.20, 0.66	0.72, 0.02 to 29.67, 0.86
	Reticular pattern extent	3.06, 1.34 to 7.01, 0.04, 0.69	1.52, 0.04 to 54.22, 0.82
	Honeycombing extent	3.79, 1.54 to 9.36, 0.02, 0.71	0.81, 0.02 to 32.13, 0.91
	Traction bronchiectasis severity	5.20, 2.19 to 12.32, 0.0009, 0.71	1.33, 0.03 to 65.14, 0.89
FVC ≥10% decline	Total ILD extent	1.45, 1.06 to 1.99, 0.10, 0.57	0.97, 0.44 to 2.15, 0.94
	Ground-glass opacity extent	1.43, 1.04 to 1.96, 0.13, 0.57	0.89, 0.42 to 1.92, 0.78
	Reticular pattern extent	1.31, 0.93 to 1.84, 0.58, 0.56	0.98, 0.43 to 2.22, 0.96
	Honeycombing extent	1.39, 0.99 to 1.95, 0.28, 0.57	0.92, 0.42 to 2.03, 0.84
	Traction bronchiectasis severity	1.63, 1.12 to 2.36, 0.049, 0.59	0.97, 0.445 to 2.10, 0.94

P values shown are adjusted for multiple comparisons.

The visual CT variables (measured with 5-point ordinal scores) were examined in separate multivariable Cox regression models adjusted for patient age, gender, baseline disease severity (using diffusion capacity for carbon monoxide) and antifibrotic use (never/ever). Analyses were performed in patients with an annualised FVC decline of 5.0%–9.9% (n=53) and ≥10% (n=107).

FVC, forced vital capacity; ILD, interstitial lung disease.