Table 2.
Univariable and multivariable analysis of the risk of screen detected lung cancer stratified according to clinical variables and PLCOM2012 score
| Variable | No | Risk of lung cancer | ||||
| Univariable | Multivariable | |||||
| OR (95% CI) | P value | adjOR* (95% CI) | P value | |||
| Emphysema | No | 504 | 1 | – | – | – |
| Yes | 883 | 1.12 (0.65 to 1.92) |
0.68 | – | – | |
| CAC | None | 328 | 1 | – | 1 | – |
| Mild | 456 | 2.44 (1.03 to 5.75) |
0.042 | 2.38 (0.996 to 5.67) |
0.051 | |
| Mod-Sev | 429 | 2.84 (1.21 to 6.65) |
0.016 | 2.62 (1.11 to 6.20) |
0.029 | |
| Symptomatic | No | 393 | 1 | – | 1 | – |
| Yes | 1007 | 2.37 (1.16 to 4.85) |
0.018 | 1.55 (0.74 to 3.28) |
0.25 | |
| FEV1/FVC ratio | 1400 | 0.97 (0.95 to 0.99) |
0.001 | 0.98 (0.96 to 1.01) |
0.19 | |
| PLCOM2012 score | 1410 | 1.13 (1.08 to 1.17) |
<0.0001 | 1.11 (1.05 to 1.16) |
<0.0001 | |
*Adjusted OR—the multivariable model included: CAC (none/mild/moderate to severe), symptomatic (yes/no), FEV1/FVC ratio and PLCOM2012 score.
CAC, coronary artery calcification; FEV1/FVC, forced expiratory volume in 1 s/forced vital capacity.