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. 2020 Jun 8;75(8):623–631. doi: 10.1136/thoraxjnl-2019-214355

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Risk of bias for included trials. (van Meenen 2018 had stated in their protocol that an economic analysis would be performed. This however was not within the trial publication. Following correspondence with authors this was a shared decision by them and the editor of JAMA. This cost related data is currently being used to prepare a separate publication to be submitted aside of the main clinical results. therefore, we assessed rob for selective outcome reporting as low.) HTS, hypertonic saline; NAC, N-acetylcysteine.