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. 2020 May 22;75(8):689–692. doi: 10.1136/thoraxjnl-2019-213878

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Scatter plots showing linear regression lines and correlation coefficients between log IgG antibody titres with time (years) after PCV13 vaccination in children with catch-up (1–2 doses), 2+1 and 3+1 schedules. The individual titres are indicated by dots. Correlation coefficients were determined with the Pearson correlation test. r, Pearson correlation coefficient. P values <0.05 were regarded as statistically significant. Solid blue line is the regression line and the shaded blue region represents 95% CI of the regression line. Panels A–H refer to serotypes 3, 6A, 6B, 7F, 14, 19A, 19F and 23F, respectively. Time since last PCV13 dose ranged from 1 month to 9 years. Serotype 19A epidemic peaked in the years 2011 and 2012 in Taiwan; this time period corresponds to 4–6 years post last PCV13 dose. IgG, immunoglobulin G; PCV13, 13-valent pneumococcal conjugate vaccine.