Figure 3.

Type 1 IFN Promoters Are Hypermethylated in Allografts from Subjects with CF

(A) Kolmogorov-Smirnoff (K-S) plot for expected DNA methylation distribution in promoters of genes related to the type 1 IFN-related gene comparing allograft brush cells from CF (n = 5) and non-CF (IPF, n = 12) recipients. The pink line is the expected distribution and the green line is the observed distribution (K-S statistic p = 0.002).

(B) Heatmap of the 12 differentially methylated IFN-related gene promoters showing relative hypermethylation of 11 promoters in CF allograft cells.