Figure 7.

The expression and function of miR‐486‐5p in NSCLC. A, Statistics from Gene Expression Omnibus dataset (GSE36681) revealed that miR‐486‐5p mRNA levels were suppressed in NSCLC tissues. B, The mRNA levels of miR‐486‐5p in six NSCLC cell lines and a normal bronchial epithelial cell line. C, The cell proliferation of miR‐486‐5p‐upregulated and negative control cells was detected by a CCK‐8 assay. D, The representative images of the colonies generated by NSCLC cells were captured. The colonies were quantified in the graph on the right. E, Upregulation of miR‐486‐5p inhibited migration and invasion of NSCLC cells, whereas knockdown of miR‐486‐5p did the opposite. F, MiR‐486‐5p‐upregulated cells moved into the scratch more slowly while miR‐486‐5p‐downregulated cells were faster in the wound‐healing assay. Each experiment was performed in triplicate. Significant differences: *P < .05, **P < .01, ***P < .001