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. 2020 Aug 5;323:62–72. doi: 10.1016/j.jbiotec.2020.07.023

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Fig. 4 — Virus and impurity recovery for different unit operation during secondary chromatography. Shown are the relative recoveries for ORFV (A) and DNA (B) during secondary purification, evaluating the Capto™ Core 700 resin (CC700), IEX-S, strong and salt-tolerant anion exchange membrane adsorbers (IEX-Q and IEX-STPA), as well as hydrophobic interaction membrane adsorbers (HICP) and the SCMA. Depicted are the quantities contained in the flow-through, wash and elution fractions, whereas for methods in the flow-through-mode (CC700 and IEX-S), flow-through and wash fractions are combined. Error bars reflect the standard deviation of technical triplicates, (IEX-S membrane was only tested once). Protein recovery is not shown for the secondary purification as already after SXC capture no protein quantities were remaining.