Fig. 3.

Area under the concentration–time curve ratios (AUCR) and maximum (peak) concentration ratios (C_maxR) of betrixaban with and without concomitantly taken drugs. Results of drug–drug interaction trials that have been conducted and published up to January 2020 are depicted [2]. A ratio equals 1 if the co-administered drug statistically insignificantly influenced direct oral anticoagulant pharmacokinetics. Green bars: AUCR and C_maxR > 0.5 and < 2. Yellow bars: AUCR and C_maxR ≤ 0.5 and ≥ 2. ¹Verapamil provided in an extended-release formulation. ²Ketoconazole 200 mg investigated. ³The antacid mixture was composed of aluminium hydroxide and magnesium hydroxide