Fig. 6.
Area under the concentration–time curve ratios (AUCR) and maximum (peak) concentration ratios (CmaxR) of rivaroxaban with and without concomitantly taken drugs. Results of drug–drug interaction trials that have been conducted and published up to January 2020 are depicted [62, 63, 69, 74, 81–83, 98, 104, 118–122]. A ratio equals 1 if the co-administered drug statistically insignificantly influenced direct oral anticoagulant (DOAC) pharmacokinetics. Green bars: AUCR and CmaxR > 0.5 and < 2. Yellow bars: AUCR and CmaxR ≤ 0.5 and ≥ 2. 1Ketoconazole 400 mg investigated. 2DOAC microdoses administered. 3Trial was performed in patients with moderate renal impairment. 4Rivaroxaban 40 mg administered. 5Ketoconazole 200 mg investigated. 6Trial was performed in patients with mild renal impairment. 7Rivaroxaban 10 mg administered. 8The antacid mixture was composed of aluminium hydroxide and magnesium hydroxide. 9Rifampicin was given repeatedly