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. 2020 Jul 29;11:445. doi: 10.3389/fendo.2020.00445

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Copyright © 2020 Chang, Lin, Shen, Su, Chuang, Lin, Liou, Lin, Weng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of MFN1/MFN2 knockdown on innate immune response in cybrid B4 under nutrient excess. (A) Representative blot image of RIG-I, MDA5, MAVS, NLRP3, and caspase-1. β-Actin as loading control. (B) Histograms of densitometric results. Quantification value of β-actin was used for normalization. *p < 0.05 compared to siRNA control in the absence of FA or between indicated groups. ^†p < 0.05 comparison between indicated groups. CON, control; FA, fatty acid.