. 2020 Jul 29;10:1278. doi: 10.3389/fonc.2020.01278

Table 3.

Multivariable models of crude and adjusted HR (95% CIs) for breast cancer recurrence, distant metastasis, and overall survival for the entire follow-up and 5-year follow-up in relation to pSTAT3^Y705 level.

BREAST CANCER RECURRENCE
							Model 1				Model 2				Model 3
	Total	Events	Crude				Adjusted				Adjusted				Adjusted
Tumor pSTAT3^Y705 status	n	n	HR	(95% CI)		P-value	HR	(95% CI)		P-value	HR	(95% CI)		P-value	HR	(95% CI)		P-value
Negative	210	40	Ref				Ref				Ref				Ref
Intermediate	606	95	0.89	0.61	1.28	0.53	0.91	0.63	1.32	0.62	1.13	0.76	1.67	0.54	1.13	0.76	1.68	0.54
High	51	2	0.24	0.06	1.00	0.051	0.26	0.06	1.07	0.061	0.41	0.10	1.74	0.23	0.39	0.09	1.62	0.19
		P_trend	0.10				0.14				0.89				0.84
Tumor pSTAT3^Y705 status	n	n	HR 5-year				HR 5-year				HR 5-year				HR 5-year
Negative	210	27	Ref				Ref				Ref				Ref
Intermediate	606	47	0.58	0.36	0.94	0.026	0.64	0.40	1.02	0.063	0.82	0.50	1.35	0.43	0.80	0.48	1.32	0.38
High	51	1	0.14	0.02	1.07	0.058	0.17	0.02	1.25	0.082	0.29	0.04	2.18	0.23	0.28	0.04	2.07	0.21
		P_trend	0.004				0.014				0.22				0.18
DISTANT METASTASIS
							Model 1				Model 2				Model 3
	Total	Events	Crude				Adjusted				Adjusted				Adjusted
Tumor pSTAT3^Y705 status	n	n	HR	(95% CI)		P-value	HR	(95% CI)		P-value	HR	(95% CI)		P-value	HR	(95% CI)		P-value
Negative	210	30	Ref				Ref				Ref				Ref
Intermediate	606	56	0.70	0.45	1.10	0.12	0.71	0.46	1.12	0.14	0.96	0.60	1.53	0.86	0.95	0.60	1.53	0.84
High	51	2	0.33	0.08	1.39	0.13	0.35	0.08	1.46	0.15	0.65	0.15	2.77	0.56	0.63	0.15	2.69	0.53
		P_trend	0.046				0.058				0.68				0.65
Tumor pSTAT3^Y705 status	n	n	HR 5-year				HR 5-year				HR 5-year				HR 5-year
Negative	210	21	Ref				Ref				Ref				Ref
Intermediate	606	28	0.45	0.26	0.79	0.006	0.48	0.27	0.85	0.011	0.66	0.36	1.19	0.17	0.64	0.35	1.17	0.15
High	51	0	No event				No event				No event				No event
		P_trend	0.0008				0.0018				0.060				0.051
DEATH
							Model 1				Model 2				Model 3
	Total	Events	Crude				Adjusted				Adjusted				Adjusted
Tumor pSTAT3^Y705 status	n	n	HR	(95% CI)		P-value	HR	(95% CI)		P-value	HR	(95% CI)		P-value	HR	(95% CI)		P-value
Negative	210	36	Ref				Ref				Ref				Ref
Intermediate	606	72	0.78	0.52	1.17	0.23	0.79	0.52	1.18	0.25	0.98	0.63	1.50	0.91	0.96	0.62	1.48	0.86
High	51	5	0.74	0.29	1.90	0.53	0.76	0.29	1.94	0.56	1.20	0.46	3.14	0.71	1.19	0.45	3.10	0.73
		P_trend	0.25				0.27				0.91				0.96
Tumor pSTAT3^Y705 status	n	n	HR 5-year				HR 5-year				HR 5-year				HR 5-year
Negative	210	25	Ref				Ref				Ref				Ref
Intermediate	606	39	0.54	0.33	0.90	0.018	0.56	0.34	0.93	0.024	0.68	0.40	1.16	0.15	0.65	0.38	1.11	0.11
High	51	1	0.17	0.02	1.24	0.080	0.18	0.02	1.31	0.089	0.29	0.04	2.14	0.22	0.28	0.04	2.11	0.22
		P_trend	0.004				0.007				0.078				0.058

Model 1: Time between surgery and staining.

Model 2: Adjusted for model 1 + age ≥50 years, tumor size, node status, grade III, ER status, HER2 status, and BMI ≥25 kg/m². Missing data for 53 patients for at least one variable.

Model 3: Adjusted for model 1 + 2 + adjuvant treatments. Missing data for 55 patients for at least one variable.